the Karakteristik faktor- faktor risiko terjadinya neuropati diabetik pada pasien diabetes melitus tipe 2 di RSI Siti Rahmah Padang Tahun 2019-2020

Karakteristik faktor- faktor risiko terjadinya neuropati diabetik

Authors

  • Suharni Departemen Mikrobiologi Fakultas Kedokteran Universitas Baiturrahmah
  • Diba Program Studi Sarjana Kedokteran Universitas Baiturrahmah
  • Aryadi Program Studi Sarjana Kedokteran Universitas Baiturrahmah

DOI:

https://doi.org/10.56260/sciena.v1i2.38

Keywords:

Neuropati diabetik, diabetes melitus tipe 2, faktor risiko

Abstract

Introduction: Diabetic neuropathy is the most common complication in patients with type 2 diabetes melitus. Type II diabetes mellitus is a disease characterized by high blood sugar levels. Increased blood sugar levels for a long time will damage the peripheral nerve vessels and cause the process of sending signals between the central nervous system and the peripheral nervous system is disrupted. This disorder is known as diabetic neuropathy. Identification of risk factors can decrease the incidence of diabetic neuropathy Aims: to determine characteristic risk factors for diabetic neuropathy in type 2 diabetes mellitus patients at RSI Siti Rahmah Padang in 2019-2020. Method: This research is an observational descriptive study with etrospective data collection methods.. The population is diabetes melitus type 2 patients with neuropathic complications at Siti Rahmah Padang Hospital in 2019-2020 who have complete medical records and no history of head trauma and stroke with a sample of 52 patients. Sampling from the medical record data of the Siti Rahmah Padang Hospital in 2019-2020.  Results: Univariate data analysis with SPSS version 16.0 program. The highest age was in the 56-65 year category ( late elderly group)  with 24 patients (46.2%), the highest gender was in the female with 36 patients (69.2%), Based on long suffering from diabetes most common is  5 years, namely 28 patients ( 53,8%) and based on hypertension state most common is with hypertension, namely 27 patients (51,9%) .Conclusion: Identification of risk factors can decrease the incidence of diabetic neuropathy

References

. PERKENI. Konsensus Penggunaan Insulin. Penatalaksanaan Diabetes Melitus Perkeni 1–9 (2019).

. Atlas, I. D. F. D. International Diabetes Federation. The Lancet vol. 266 (2019)

. Kemenkes RI. Hasil Riset Kesehatan Dasar Tahun 2018. Kementrian Kesehatan. RI 53, 1689–1699 (2018).

. Simanjuntak, G. V. & Simamora, M. Lama menderita diabetes melitus tipe 2 sebagai faktor risiko neuropati perifer diabetik. Holistik J. Kesehat. 14, 96–100 (2020).

. Hicks, C. W. & Selvin, E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr. Diab. Rep. 19, (2019)

. Feldman, E. L. et al. Diabetic neuropathy. Nat. Rev. Dis. Prim. 5, (2019).

. Putri, A. M., Hasneli, Y. & Safri. Faktor-Faktor Yang Mempengaruhi Derajat Keparahan Neuropati Perifer Pada Pasien Diabetes Melitus : Literature Review. J. Ilmu Keperawatan 8, 38–53 (2020)

. Ketut, S. Penuaan, Insulin, dan Diabetes.Jakarta: PT Gramedia Pustaka Utama (2018).

. Rajchgot, T. et al. Neurons and microglia; a sickly-sweet duo in diabetic pain neuropathy. Front. Neurosci. 13, 1–17 (2019)

. Chia, C. W., Egan, J. M. & Ferrucci, L. Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk. Circ. Res. 123, 886–904 (2018).

. Shepard BD. Sex differences in diabetes and kidney disease: mechanisms and consequences. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F456-F462. doi: 10.1152/ajprenal.00249.2019. Epub 2019 Jun 26. PMID: 31241989; PMCID: PMC6732459

. Mildawati, Diani, N. & Wahid, A. Hubungan Usia, Jenis Kelamin dan Lama Menderita Diabetes dengan Kejadian Neuropati Perifer Diabetik. Caring Nurs. J. 3, 31–37 (2019)

. Amelia, R., Wahyuni, A. S. & Yunanda, Y. Diabetic neuropathy among type 2 diabetes mellitus patients at amplas primary health care in Medan city. Open Access Maced. J. Med. Sci. 7, 3400–3403 (2019).

. Kooptiwut S, Hanchang W, Semprasert N, Junking M, Limjindaporn T, Yenchitsomanus PT. Testosterone reduces AGTR1 expression to prevent β-cell and islet apoptosis from glucotoxicity. J Endocrinol 224: 215–224, 2015. doi:10.1530/JOE-14-0397. [PubMed: 25512346] [CrossRef: 10.1530/JOE-14-0397]

. Mauvais-Jarvis, F., Manson, J. E., Stevenson, J. C., Fonseca, V. A. Menopausal hormone therapy and type 2 diabetes prevention: Evidence, mechanisms and clinical implications. Endocr Rev. 2017.

. Ardiyati, A.V.(2014). Hubungan Antara Skor Monofilamen Dengan Ulkus Diabetik Di Klinik Perawatan Luka Rumat Bekasi. (Skripsi tidak dipublikasi). Program Studi Ilmu Keperawatan Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Syarif Hidayatullah, Jakarta

. Fery LS, Agus T. Korelasi Lama Menderita Diabetes Mellitus ( DM) Tipe 2 dengan Kejadian Neuropati DM Pada Pasien Prolanis di Ngemplak, Sleman. Jurnal Ilmiah Simantek Vol.5 No. 3 : 88-93.(2021)

. Monnier VM, Genuth S, Sell DR. The pecking order of skin Asvanced Glycation Endproducts (AGEs) as long tem markers of glycemic damage and risk factors for micro- and subclinical macrovascular disease progression. GlycoconJ 567-79. (2016)

. Testa, R. et al. The ‘Metabolic Memory’ Theory and the Early Treatment of Hyperglycemia in Prevention of Diabetic Complications. Nutrients 9, (2017).

. Duarsa, M. D. V. I., Arimbawa, I. K. & Indrayani, I. A. S. Hipertensi sebagai Faktor Risiko Nyeri Neuropati Diabetik pada Pasien Diabetes Mellitus Tipe II di RSUP Sanglah Denpasar. Med. Udayana 8, 1–6 (2019).

. Lingning H, Yongze Z, et all. Diabetic Peripheral Neuropathy is Associated With Higher Systolic Blood Pressure in Adults With Type 2 Diabetes With and Without Hypertension in the Chinese Han Population. Canadian Journal of Diabetes. Vol.44 615-623 (2020).

. Rahmawati, A. & Hargono, A. Dominant Factor of Diabetik Neuropathy on Diabetes Mellitus Type 2 Patients. J. Berk. Epidemiol. 6, 60 (2018).

. Ozaki, K. & Matsuura, T. Superimposition of hypertension on diabetic peripheral neuropathy affects small unmyelinated sensory nerves in the skin and myelinated tibial and sural nerves in rats with alloxan-induced type 1 diabetes. J. Toxicol. Pathol. 33, 161–169 (2020).

. Davidson EP, Holmes A, Coppey LJ, and Yorek MA. Effect of combination therapy consisting of enalapril, α-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/ low dose streptozotocin treated rat. Eur J Pharmacol. 765: 258–267. 2015.

. Sabbatini M, Bellagamba G, Vega JA, and Amenta F. Effect of antihypertensive treatment on peripheral nerve vasculature in spontaneously hypertensive rats. Clin Exp Hypertens. 23: 157–166. 2001.

. Ozaki K, Hamano H, Matsuura T, and Narama I. Effect of deoxycorticosterone acetate-salt-induced hypertension on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats. J Toxicol Pathol. 29: 1–6. 2016.

. Alshaya, A. K. et al. The Common Complications and Comorbidities among Saudi Diabetic Patients in Northern Saudi Arabia. Open J. Endocr. Metab. Dis. 07, 151–161 (2017).

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Published

2022-03-30

How to Cite

Suharni, Diba Triulandari Kusnadi, & Zulkarnaini, A. (2022). the Karakteristik faktor- faktor risiko terjadinya neuropati diabetik pada pasien diabetes melitus tipe 2 di RSI Siti Rahmah Padang Tahun 2019-2020: Karakteristik faktor- faktor risiko terjadinya neuropati diabetik. Scientific Journal, 1(2), 94–100. https://doi.org/10.56260/sciena.v1i2.38

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Section

Research in Biomedical Science