https://journal.scientic.id/index.php/sciena <p><span style="color: #008000;"><strong>Scientific Journal(SCIENA)</strong></span> published by an official of Scientific.id_considers the following types of original contribution for peer review and publication: Research Articles, Review Articles, Letters to Editor, Brief Communications, Case Reports, Book Reviews, Technological Reports, and Opinion Articles. It Is published six times a year and serves the need of scientific and non-scientific personals involved/interested in Natural Science (Physics, Chemistry, Electronics, Mathematics, Astronomy, Oceanography, Engineering), Social Science, Economics, Biology and Medicine. Each issue covers topics, which are of broad readership interest to personals from General Public, Industry, Clinicians, Academia, and Government. Scientic Journal is a must read journal for every one with curiosity in science.</p> <p><span style="color: #3366ff;">Submissions</span> are welcome from other clinically relevant areas. However, the Journal emphasizes publishing high-quality and novel research.</p> <p><span lang="en"> </span></p> CV. AKBAR PUTRA MANDIRI en-US Scientific Journal 2810-0204 https://journal.scientic.id/index.php/sciena/article/view/357 <p><strong>Background:</strong> Opioid-Free Anesthesia (OFA) has emerged as a revolutionary paradigm utilizing non-opioid multimodal analgesia to achieve stable nociceptive control without intraoperative opioids. This review evaluates the clinical evidence, practical applications, and implementation challenges of OFA. <strong>Methods:</strong> A comprehensive literature review was conducted across PubMed, ScienceDirect, and Google Scholar, selecting randomized controlled trials (RCTs) from the last five years. Data extracted included study designs, surgical typologies, pharmacological regimens, and clinical outcomes. <strong>Results:</strong> OFA provides non-inferior intraoperative stability and analgesia while significantly enhancing recovery scores, sleep quality, and PONV reduction. However, its efficacy is surgical-specific: it markedly reduces morphine needs in visceral procedures (bariatric/colorectal) but offers no advantage over optimized opioid-sparing anesthesia in musculoskeletal surgeries like total hip arthroplasty. Furthermore, high-dose non-opioid adjuncts introduce challenges like prolonged extubation, increased PACU stay, and sympathetic fluctuations. <strong>Conclusion:</strong> OFA is a safe and effective technique that minimizes opioid-related complications and improves recovery, particularly for high-risk patients and oncological surgeries. However, its benefits are surgical-specific and not universally superior to optimized Opioid-Sparing Anesthesia (OSA). Future universal adoption requires standardized dosing and objective monitoring (pEEG and Surgical Pleth Index) to ensure predictable recovery.</p> Rialta Hamda Rahma Yulia Putri Annisa Lidra Maribeth Copyright (c) 2026 Rialta Hamda, Rahma Yulia Putri, Annisa Lidra Maribeth https://creativecommons.org/licenses/by-nc-sa/4.0 2026-07-02 2026-07-02 5 4 386 395 10.56260/sciena.v5i4.357 https://journal.scientic.id/index.php/sciena/article/view/381 <p><strong>Latar Belakang:</strong> Tuberkuloma serebral merupakan manifestasi tuberkulosis sistem saraf pusat yang jarang dan dapat menyerupai neoplasma intrakranial secara klinis maupun radiologis. Variabilitas pencitraan serta persistensi lesi setelah terapi antituberkulosis dapat menimbulkan tantangan diagnostik dan terapeutik. <strong>Laporan Kasus:</strong> Seorang laki-laki berusia 18 tahun datang dengan riwayat kejang umum tonik berulang selama satu tahun, disertai riwayat batuk kronis, penurunan berat badan, demam hilang-timbul, dan keringat malam. Rontgen toraks menunjukkan tuberkulosis paru dan tes cepat molekuler <em>Mycobacterium tuberculosis</em> positif. CT-scan kepala tanpa kontras awalnya mengarah pada ganglioglioma. MRI otak dengan kontras selanjutnya menunjukkan multipel <em>ring-enhancing lesions</em> pada lobus parietal kanan dan oksipital kiri. Konvergensi temuan klinis, bukti tuberkulosis sistemik, dan pencitraan mendukung diagnosis Tuberkuloma Serebral Multipel dengan Epilepsi Simptomatik. Pasien mendapat terapi antituberkulosis selama 12 bulan dan fenitoin, tanpa kekambuhan kejang. MRI satu bulan setelah terapi menunjukkan resolusi lesi oksipital kiri dan regresi parsial lesi parietal kanan. Tanpa perpanjangan terapi antituberkulosis, MRI 14 bulan setelah terapi menunjukkan resolusi radiologis total. <strong>Kesimpulan:</strong> Integrasi temuan klinis, bukti tuberkulosis sistemik, dan MRI penting dalam membedakan tuberkuloma serebral dari neoplasma intrakranial. Persistensi lesi residual setelah terapi tidak selalu menunjukkan kegagalan terapi apabila disertai perbaikan klinis yang konsisten. MRI serial berperan penting dalam mengevaluasi respons dan mendokumentasikan resolusi bertahap tuberkuloma.</p> Tati Khairina Athiya Rahmah Elsafrediniya Fredia Heppy Yanti Fitri Yasa Copyright (c) 2026 Tati Khairina, Athiya Rahmah Elsafrediniya , Fredia Heppy, Yanti Fitri Yasa https://creativecommons.org/licenses/by-nc-sa/4.0 2026-07-07 2026-07-07 5 4 381 406 10.56260/sciena.v5i4.381